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Trial Radar • ClinicalTrials.gov • Registry-linked

Trial Radar

2236 clinical trials with phase, status, specialty and registry links, summarised for rapid clinical review.

2236 recruiting AI clinical summaries
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All Phases Phase I Phase II Phase III Phase IV
Therapeutic Area: All Cardiology / Cardiovascular Dermatology Diabetes / Metabolic Gastroenterology Haematology Infectious Disease Men's Health Mental Health / Psychiatry Nephrology Neurology Oncology Rare Diseases
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Trial Radar

Clinical Trial Intelligence

● Recruiting Phase II Oncology
A Study of Amivantamab in Participants With Advanced or Metastatic Solid Tumors Including Epidermal Growth Factor Receptor (EGFR)-Mutated Non-Small Cell Lung Cancer
What is being tested: Amivantamab (a bispecific antibody targeting EGFR and MET) administered subcutaneously with recombinant human hyaluronidase in combination regimens, primarily for advanced/metastatic…
14 Apr 2026 NCT05498428
● Recruiting Phase II Oncology
A Study of Amivantamab in Combination With Lazertinib, or Amivantamab in Combination With Platinum-Based Chemotherapy, for Common Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)
Treatment being tested: Amivantamab (a bispecific antibody) combined with either lazertinib (a third-generation EGFR tyrosine kinase inhibitor) or platinum-based chemotherapy in patients with EGFR-mutated…
14 Apr 2026 NCT06667076
● Recruiting Phase II Oncology
To Study the Effect of Inavolisib in Combination With Fulvestrant in Participants With Breast Cancer
What is being tested: Inavolisib (a PI3K inhibitor) combined with fulvestrant (an oestrogen receptor degrader) in patients with PIK3CA-mutated, hormone receptor-positive, HER2-negative locally advanced…
14 Apr 2026 NCT07368998
● Recruiting Phase I Oncology
Study of INCB123667 in Subjects With Advanced Solid Tumors
Drug Being Tested: INCB123667 is a novel investigational agent being evaluated for safety, tolerability, pharmacokinetics, and anti-tumour efficacy in advanced/metastatic solid tumours, tested both…
14 Apr 2026 NCT05238922
● Recruiting Neurology
Registry of Deep Brain Stimulation With the VERCISE™ System: Vercise DBS Registry
What is being tested: Real-world outcomes and effectiveness of Boston Scientific's Vercise DBS System for Parkinson's disease treatment, including the role of Image Guided…
14 Apr 2026 NCT02071134
● Recruiting Phase III Cardiology / Cardiovascular
A Study to Learn More About How Safe the Study Treatment Finerenone is in Long-term Use When Taken With an ACE Inhibitor or Angiotensin Receptor Blocker Over 18 Months of Use in Children and Young Adults From 1 to 18 Years of Age With Chronic Kidney Disease and Proteinuria
What is being tested: Finerenone (a non-steroidal mineralocorticoid receptor antagonist) safety and tolerability in children and young adults aged 1-18 years with chronic kidney…
14 Apr 2026 NCT05457283
● Recruiting Phase III
A Study to Evaluate the Efficacy and Safety of Sefaxersen (RO7434656) in Participants With Primary Immunoglobulin A (IgA) Nephropathy at High Risk of Progression
What is being tested: Sefaxersen (RO7434656), a novel antisense oligonucleotide therapy designed to reduce kidney disease progression in patients with primary IgA nephropathy who…
14 Apr 2026 NCT05797610
● Recruiting Phase III
Long-term Efficacy, Safety and Tolerability of Iptacopan in C3G or IC-MPGN
What is being tested: Long-term efficacy, safety and tolerability of iptacopan, a Factor B inhibitor targeting the alternative complement pathway, in patients with C3…
14 Apr 2026 NCT03955445
● Recruiting Phase III Rheumatology
A Long-term Extension (LTE) Study of Guselkumab in Pediatric Participants
Treatment being tested: Long-term safety and efficacy of guselkumab (an IL-23 inhibitor administered subcutaneously) in pediatric patients with moderately to severely active ulcerative colitis,…
14 Apr 2026 NCT06663332
● Recruiting Phase II Rheumatology
A Study on the Safety of TAK-279 and Whether it Can Reduce Inflammation in the Bowel of Participants With Moderately to Severely Active Crohn’s Disease
Investigational agent: TAK-279, a novel therapeutic agent, is being tested for its efficacy and safety in reducing bowel inflammation specifically in patients with moderately…
14 Apr 2026 NCT06233461
● Recruiting Phase III Rheumatology
A Protocol of Icotrokinra Therapy in Adult and Adolescent Participants With Moderately to Severely Active Ulcerative Colitis
What is being tested: Oral icotrokinra, a novel therapeutic agent, is being evaluated for its efficacy, safety, and tolerability in treating moderately to severely…
14 Apr 2026 NCT07196748
● Recruiting Respiratory / COPD / Asthma
Biologics and Paediatric Enteral Nutrition in Crohn’s Disease Study
What is being tested: This study evaluates the effectiveness and safety of biologic medications (injectable drugs targeting inflammation) compared to enteral nutrition therapy (specialised…
14 Apr 2026 NCT07522528
● Recruiting Respiratory / COPD / Asthma
The PARS Study: Paediatric Advanced Respiratory Service Study – An Observational Diagnostic Feasibility Study
What is being tested: The feasibility of using advanced diagnostic investigations (adapted for smaller patient size and improved tolerability) to identify sleep-disordered breathing in…
14 Apr 2026 NCT06292299
● Recruiting Respiratory / COPD / Asthma
Using Multiomics to Define Mechanisms of Rhinovirus-induced Chronic Obstructive Pulmonary Disease Exacerbations to Develop Novel Therapies and Therapeutic Targets
What is being tested: Multi-omics analysis of rhinovirus-induced COPD exacerbations to identify underlying biological mechanisms and develop novel therapeutic targets and treatments for this…
14 Apr 2026 NCT07112235
● Recruiting Respiratory / COPD / Asthma
Capillary OGTT Study
What is being tested: Capillary (fingerprick) oral glucose tolerance testing (OGTT) as an alternative to venous blood sampling for identifying stage 2 type 1…
14 Apr 2026 NCT06815081
● Recruiting Phase III Cardiology / Cardiovascular
A Study of Milvexian in Participants After an Acute Ischemic Stroke or High-Risk Transient Ischemic Attack- LIBREXIA-STROKE
What is being tested: Milvexian, a Factor XIa inhibitor, is being evaluated as a novel anticoagulant to reduce recurrent ischemic stroke risk compared to…
14 Apr 2026 NCT05702034
● Recruiting Cardiology / Cardiovascular
Study of the Long-Term Safety and Outcomes of Treating Pulmonary Embolism With the Indigo Aspiration System
What is being tested: Long-term safety, performance, and functional outcomes of the Indigo Aspiration System, a mechanical thrombectomy device designed to remove blood clots…
14 Apr 2026 NCT04798261
● Recruiting Phase III Cardiology / Cardiovascular
Efficacy and Safety Study of Treprostinil Palmitil Inhalation Powder (TPIP) in Participants With Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)
Intervention being tested: Treprostinil palmitil inhalation powder (TPIP) administered once daily for 24 weeks as a potential treatment for pulmonary hypertension associated with interstitial…
14 Apr 2026 NCT07179380
● Recruiting Phase I Oncology
An Open-label Dose Escalation and Expansion, Followed by a Phase II Study of Tulmimetostat (DZR123) and JSB462 (Luxdegalutamide) in Patients With Progressive Metastatic Castrate Resistant Prostate Cancer (mCRPC) (TulmiSTAR-01)
Treatment being tested: A combination of two novel agents—tulmimetostat (DZR123), a targeted therapy, and JSB462 (luxdegalutamide), a GLP-1 receptor agonist—evaluated against standard of care…
14 Apr 2026 NCT07206056
● Recruiting Phase II Oncology
A Study of JNJ-90301900 in Combination With Chemoradiation Followed by Consolidation Immunotherapy for Non-Small Cell Lung Cancer (NSCLC)
What is being tested: JNJ-90301900 (an investigational immunotherapy agent) combined with standard concurrent platinum-based chemotherapy and radiation therapy, followed by consolidation immunotherapy, to determine…
14 Apr 2026 NCT06667908
● Recruiting Phase I Oncology
Clinical Trial Evaluating the Safety, Tolerability and Preliminary Efficacy of BNT116 Alone and in Combinations in Patients With Advanced Non-small Cell Lung Cancer
BNT116 is a first-in-human immunotherapy being evaluated as monotherapy and in combination regimens for advanced non-small cell lung cancer (NSCLC), with the primary aim…
14 Apr 2026 NCT05142189
● Recruiting Phase III Oncology
A Study to Compare the Efficacy and Safety of BMS-986393 Versus Standard Regimens in Adult Participants With Relapsed or Refractory and Lenalidomide-exposed Multiple Myeloma (QUINTESSENTIAL-2)
What is being tested: BMS-986393 (arlo-cel), a novel therapeutic agent, is being compared against standard treatment regimens in patients with relapsed or refractory multiple…
14 Apr 2026 NCT06615479
● Recruiting Phase III Oncology
ONC-392 Versus Docetaxel in Metastatic NSCLC That Progressed on PD-1/PD-L1 Inhibitors
What is being tested: ONC-392 (gotistobart), a next-generation anti-CTLA-4 antibody, is being compared against standard docetaxel chemotherapy in patients with metastatic non-small cell lung…
14 Apr 2026 NCT05671510
● Recruiting Phase III Oncology
Saruparib (AZD5305) Plus Camizestrant Compared With CDK4/6 Inhibitor Plus Endocrine Therapy or Plus Camizestrant in HR-Positive, HER2-Negative (IHC 0, 1+, 2+/ ISH Non-amplified), BRCA1, BRCA2, or PALB2m Advanced Breast Cancer
What is being tested: Saruparib (a PARP inhibitor) combined with camizestrant (an estrogen receptor degrader) versus standard CDK4/6 inhibitor plus endocrine therapy in patients…
14 Apr 2026 NCT06380751
● Recruiting Phase II Oncology
A Study of INCB123667 in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression
Drug being tested: INCB123667, a novel therapeutic agent being evaluated for safety and efficacy in patients with platinum-resistant ovarian cancer (PROC) who have Cyclin…
14 Apr 2026 NCT07023627
● Recruiting Phase II Oncology
A Study of Amivantamab in Combination With Lazertinib, or Amivantamab in Combination With Platinum-Based Chemotherapy, for Common Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)
Two drug combinations tested for advanced lung cancer with EGFR mutations: amivantamab plus lazertinib versus amivantamab plus chemotherapy.
13 Apr 2026 NCT06667076
● Recruiting
A Study on Hemolytic Disease of the Fetus and Newborn (HDFN) Through Global Registry
Global registry tracking anemia risk in babies of mothers at risk for blood incompatibility disease receiving standard care.
13 Apr 2026 NCT07194070
active not recruiting Phase III
A Study Comparing JNJ-68284528, a CAR-T Therapy Directed Against B-cell Maturation Antigen (BCMA), Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) or Daratumumab, Pomalidomide and Dexamethasone (DPd) in Participants With Relapsed and Lenalidomide-Refractory Multiple Myeloma
CAR-T cell therapy cilta-cel compared with standard chemotherapy in patients with relapsed multiple myeloma resistant to lenalidomide.
13 Apr 2026 NCT04181827
● Recruiting Phase III
A Study of Bleximenib, Venetoclax and Azacitidine For Treatment of Participants With Newly Diagnosed Acute Myeloid Leukemia (AML)
Trial testing whether adding bleximenib to venetoclax-azacitidine improves outcomes in newly diagnosed AML with specific genetic mutations.
13 Apr 2026 NCT06852222
active not recruiting
ATTUNE® Revision- Complex Primary in Total Knee Arthroplasty Population
ATTUNE® Revision knee implants showed good five-year outcomes in complex primary knee replacement surgery using fixed or rotating tibial components.
13 Apr 2026 NCT03153449
active not recruiting Phase III Oncology
A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for Treatment of Participants With Metastatic Prostate Cancer
Adding niraparib to standard prostate cancer treatment (abiraterone and prednisone) delays cancer progression compared to standard treatment alone.
13 Apr 2026 NCT03748641
active not recruiting Phase II Cardiology / Cardiovascular
A Study of Daratumumab-Based Therapies in Participants With Amyloid Light Chain (AL) Amyloidosis
Trial testing a new drug combination for heart-involved amyloid disease, comparing immediate versus delayed treatment timing.
13 Apr 2026 NCT05250973
● Recruiting Phase II / Phase III
A Study to Evaluate the Effect of Aficamten in Pediatric Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy (oHCM).
Aficamten improves symptoms and safety in children with obstructive hypertrophic cardiomyopathy, a serious heart muscle condition.
13 Apr 2026 NCT06412666
● Recruiting
Abbott Structural Heart Device Registry
Real-world safety study tracking Abbott's heart devices after commercial release to meet regulatory requirements.
13 Apr 2026 NCT06590467
● Recruiting Phase III Oncology
Study of Subcutaneous Epcoritamab in Combination With Intravenous Rituximab and Oral Lenalidomide (R2) to Assess Adverse Events and Change in Disease Activity in Adult Participants With Previously Untreated Follicular Lymphoma
Trial testing new drug epcoritamab combined with existing treatments for untreated follicular lymphoma, measuring safety and effectiveness in 1095 patients.
13 Apr 2026 NCT06191744
● Recruiting Phase II Oncology
A Study of Amivantamab in Participants With Advanced or Metastatic Solid Tumors Including Epidermal Growth Factor Receptor (EGFR)-Mutated Non-Small Cell Lung Cancer
Amivantamab injection tested for safety and effectiveness in advanced cancers, particularly lung cancer with specific genetic mutations.
13 Apr 2026 NCT05498428
● Recruiting Phase III Infectious Disease
BEATRIX: A Study to Learn About a Group B Streptococcus Vaccine in Healthy Pregnant Women and Their Babies
Trial testing a group B streptococcus vaccine in pregnant women and babies to assess safety and immune response.
13 Apr 2026 NCT07160244
● Recruiting Phase III Oncology
A Study of Camizestrant in ER+/HER2- Early Breast Cancer After at Least 2 Years of Standard Adjuvant Endocrine Therapy
New hormone therapy drug tested against standard treatment in early breast cancer patients who've completed two years of initial hormone therapy.
13 Apr 2026 NCT05774951
active not recruiting Phase II Cardiology / Cardiovascular
A Clinical Study of to Confirm the Doses of Selexipag in Children With Pulmonary Arterial Hypertension
Study testing whether adult-based selexipag doses produce similar blood levels in children aged 2-18 with pulmonary arterial hypertension.
13 Apr 2026 NCT03492177
active not recruiting Phase III Oncology
A Study of TAR-200 Versus Intravesical Chemotherapy in Participants With Recurrent High-Risk Non-Muscle-Invasive Bladder Cancer (HR-NMIBC) After Bacillus Calmette-Guérin (BCG)
TAR-200 compared to standard chemotherapy for bladder cancer recurrence after BCG in patients refusing surgery.
13 Apr 2026 NCT06211764
active not recruiting Phase I Oncology
A Study of Comparative Formulations of Niraparib and Abiraterone Acetate (AA) in Men With Prostate Cancer
This trial compares different formulations of niraparib and abiraterone acetate to ensure they work similarly in men with advanced prostate cancer.
13 Apr 2026 NCT04577833
● Recruiting Oncology
Clinical Investigation Evaluating the Performance, Safety and Clinical Benefit of the Endowave FlexAblate™ Microwave Ablation System in Patients Undergoing Lung Ablation Procedures.
What is being tested: The Endowave FlexAblate™ Microwave Ablation System's effectiveness and safety profile for treating lung cancer nodules using microwave ablation technology as…
10 Apr 2026 NCT07291973
● Recruiting Phase II
BAY3401016; Biomarker Study Alport
What is being tested: BAY3401016 is being investigated as a potential therapeutic intervention in Alport syndrome, a rare genetic disorder caused by mutations in…
10 Apr 2026 NCT07211685
● Recruiting Phase II
A Phase 2 Study of MZE829 in Adults With APOL1 Kidney Disease
What is being tested: MZE829, an investigational therapeutic agent, is being evaluated for its safety, tolerability, and ability to reduce albuminuria (protein in urine)…
10 Apr 2026 NCT06830629
● Recruiting Phase I Respiratory / COPD / Asthma
NAL ER IPF Respiratory Function and Safety Study
What is being tested: Escalating doses of NAL ER (N-acetylcysteine extended-release) to evaluate its safety, tolerability, and effects on respiratory function in idiopathic pulmonary…
10 Apr 2026 NCT07036029
● Recruiting Phase II Respiratory / COPD / Asthma
Long-term Safety and Efficacy Evaluation of Lunsekimig (SAR443765) in Adult Participants With Asthma.
Treatment being tested: Lunsekimig (SAR443765), a novel therapeutic agent, is being evaluated for long-term safety and efficacy in adults with asthma through an open-label…
10 Apr 2026 NCT06609239
● Recruiting Phase II Respiratory / COPD / Asthma
A Study to Evaluate Axatilimab Versus Best Available Therapy in Pediatric Participants With Chronic Graft-Versus-Host Disease After at Least 2 Prior Lines of Systemic Therapy (AGAVE-256)
What is being tested: Axatilimab (a CSF1R inhibitor) is being evaluated against best available therapy in paediatric patients with chronic graft-versus-host disease (cGVHD) who…
10 Apr 2026 NCT07124078
● Recruiting Phase III Respiratory / COPD / Asthma
Depemokimab as an Extended treatmeNt Duration Biologic in Adults With Chronic Obstructive Pulmonary Disease (COPD) and Type 2 Inflammation (ENDURA-2)
What is being tested: Depemokimab, a biologic therapy administered as an add-on treatment, is being evaluated for efficacy and safety in patients with uncontrolled…
10 Apr 2026 NCT06961214
● Recruiting Phase II Cardiology / Cardiovascular
Treatment of Acute Ischemic Stroke (ReMEDy2 Trial)
What is being tested: DM199 (rinvecalinase alfa), a novel therapeutic agent designed to improve outcomes in acute ischemic stroke caused by small and medium…
10 Apr 2026 NCT05065216
● Recruiting Cardiology / Cardiovascular
Streamlined Denervation With spYral For an Optimized Treatment (SPYRAL SWYFT) in Subjects With Uncontrolled Hypertension
What is being tested: The Symplicity Spyral catheter system for renal denervation targeting the main and first-order branch renal arteries to achieve shorter procedure…
10 Apr 2026 NCT07115953